This is semi-conservative replication and was first demonstrated experimentally by Meselson and Stahl, who showed that newly synthesised DNA is composed of Visualization of DNA Replication in Single Chromosome by Stable Isotope Labeling. Kosuke Nagata, Ken-ichi Bajo, Hideyuki Mitomo, Ryosuke Fujita, Ryota U The first method involves the production of RNA molecules in vitro by using purified polymerase and DNA templates or through direct chemical synthesis
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